metronidazole fish
Thursday, March 11th, 2010
Rheumatoid arthritis (RA) is the most common of several autoimmune diseases mainly affecting the joints.
It is characterized by a response abnormal inflammatory damage to the synovial lining of the joints and other tissues. The components of the immune system to mistakenly identify the body tissues normal and potentially harmful organisms and attack causing major collateral damage.
This results in joint pain, inflammation and permanent damage to joint cartilage and underlying bone. Other body parts such as blood, nerve and heart may also be affected in severe cases.
Furthermore, conventional drugs used in the treatment of RA often cause many health problems as the disease itself. Marrow marrow and immune suppression, liver toxicity, osteoporosis and stomach ulcers are some common side effects caused by these drugs.
While antibiotics also have potential side effects, usually fewer and milder than those associated with conventional drugs used to treat of RA.
TYPES OF INFECTIONS CAUSING RHEUMATOID ARTHRITIS
Most scientists agree that the response starts infections abnormal inflammatory seen in patients with RA. The theory is that the immune system reacts to an infection of some sort and then blends into the antigens pathogens in the body and similar antigens in normal tissues of the body. The conventional view is that the infection is only a trigger transient response autoimmune and not an underlying factor of persistent chronic progression.
However, numerous studies have shown that there is indeed a series of chronicles, "occult" infections underlying RA. Some of the pathogenic organisms found in the joints of rheumatoid arthritis patients but most of these low-grade infections occur in areas such as genito-urinary tract, mouth or intestines. They work indirectly in these areas for the maintenance of the inflammatory response abnormal, so characteristic of RA.
Mycoplasma, Chlamydia, E. coli and Proteus are all bacteria that are capable of causing the poor quality asymptomatic urinary tract infections underlying RA.
Porphyromonas gingivalis, a bacterium that causes gingivitis and periodontitis and also has a strong Assoc
iation with RA.
Although often laboratory tests confirm the presence of one or more of these infections, negative results do not opposed to an infectious cause of illness of an individual.
Because many of the underlying RA infections are so difficult to find, even those patients have no positive laboratory tests should be treated with antibiotics.
ANTBIOTICS USED TO TREAT RHEUMATOID ARTHRITIS
During many years the basis of antibiotic treatment for RA has been the minocycline or tetracycline and doxycycline. Those of antibiotics are still very useful as they also have anti-inflammatory properties and stimulate regeneration of damaged joint cartilage.
However, many bacteria have developed tetracycline resistance and is now common practice to use combinations with other antibacterials such as azithromycin, clindamycin, metronidazole, levofloxacin, and others.
OUTCOME OF ANTIBIOTIC TREATMENT OF RA
Patients may notice improvements in their symptoms anywhere in days weeks or months, depending on how long they have the disease. They should also be expected to remain on antibiotics for several months over a year until produces a complete remission.
The information on doctors who have used this for many years show that at least 80% of patients benefit from this relatively simple treatment modality.
Why is an effective treatment is not widely available
There are two reasons for the delay in getting this "new" treatment more widely accepted:
First is the research "gap effect "? the period that elapses from the moment that new medical discovery is made until it is accepted and applied by most doctors. This interval can be more than 20 long years.
Second, despite ample evidence that some organisms are associated with rheumatoid arthritis and other diseases autoimmune, no specific organism has proven to be responsible for this group of diseases. This is due to autoimmune diseases comprise a broad range of conditions accumulation may be caused by several types of microbes located in various parts of the body.
REFERENCES
1. Effects clarithromycin in patients with active rheumatoid arthritis, Curr Med Res Opin. 2007 Mar; 23 (3) :515-22
Levofloxacin 2. In patients with rheumatoid rheumatoid arthritis receiving methotrexate, M Ogrendik, South Med J. 2007 Feb; 100 (2) :135-9.
3. Single blind randomized trial of combinations of antibiotics in rheumatoid arthritis, Gompels LL, Smith A, Charles PJ, Rogers W, Soon-Shiong J, Mitchell A, Dore C, Taylor PW, Mackworth-Young CG. J Rheumatol. 2006 Feb; 33 (2) :224-7.
4. Treatment of early seropositive rheumatoid arthritis: Doxycycline plus methotrexate versus methotrexate alone. O'Dell JR, Elliott JR, Mallek JA, Mikuls TR, Weaver CA, Glickstein S, Blakely KM, Hausch R, Leff RD, Arthritis Rheum. 2006 Feb; 54 (2) :621-7. University of Nebraska Medical Center, Omaha.
5. Treatment of early seropositive rheumatoid arthritis: in two years, double-blind comparison of minocycline and hydroxychloroquine. O'Dell JR, Blakely KW, Mallek JA, Eckhoff PJ, Leff RD, Wees SJ, sems KM, Fernandez, AM, Palmer WR, Klassen LW, Paulsen GA, Haire CE, Moore GF – Arthritis & Rheumatism 2001 Oct; 44 (10) :2235-41
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